DYFED-Powys Police is investigating a burglary that occurred sometime overnight on Monday, 30th April at Rembrandts Jewellers, Tudor Square, Tenby.
The crime was reported to police at 8.40am on Tuesday, 1st May, when the shop was due to be opened.
Around £40,000 worth of jewellery and cash was taken.
Officers are following all lines of enquiry to track down the offenders.
Anyone with information that can help officers with their investigation, particularly anyone in the vicinity of Tudor Square or Crackwell Street, Tenby, overnight Monday into Tuesday is asked to report it by calling 101.
If you are deaf, hard of hearing or speech impaired text the non-emergency number on 07811 311 908, quoting Ref: 045 of May 1.